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• 3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex
• A 3D cellular context for the macromolecular world.
• ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.
• An Open Science Peer Review Oath
• Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging.
• BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.
• Binding of polyamines to an autonomous domain of the regulatory subunit of protein kinase CK2 induces a conformational change in the holoenzyme. A proposed role for the kinase stimulation.
• Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase.
• Correlative live and super-resolution imaging reveals the dynamic structure of replication domains
• Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay.
• Experimental and computational framework for a dynamic protein atlas of human cell division.
• FUN-L: gene prioritization for RNAi screens.
• Finding and sharing: new approaches to registries of databases and services for the biomedical sciences.
• Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.
• High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.
• High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes.
• How can functional annotations be derived from profiles of phenotypic annotations?
• Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data.
• Integrating imaging and omics: Computational methods and challenges.
• Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.
• Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila.
• LOMAR: LOcalization Microscopy Analysis in R
• Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1.
• Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.
• Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings
• Profiling DNA damage response following mitotic perturbations
• Protein kinase CK2alpha is a target for the Abl and Bcr-Abl tyrosine kinases.
• Quantitative analysis of chromosome condensation in fission yeast.
• RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expression.
• Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha.
• Simulating structurally variable Nuclear Pore Complexes for Microscopy
• Systematic analysis of human protein complexes identifies chromosome segregation proteins.
• Systematic computational prediction of protein interaction networks.
• Systematic phosphorylation analysis of human mitotic protein complexes.
• TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
• The Image Data Explorer: interactive exploration of image-derived data
• The Open Science Peer Review Oath
• The cellular microscopy phenotype ontology.
• The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.
• Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation
• TreeFam: 2008 Update.
• TreeFam: a curated database of phylogenetic trees of animal gene families.
• Visualization of image data from cells to organisms.
• Visualizing biological data-now and in the future.