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• A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells.
• Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage
• Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.
• Altered nuclear envelope structure and proteasome function of micronuclei.
• An ESCRT-LEM domain inner nuclear membrane protein surveillance system is poised to directly monitor the integrity of the nuclear envelope barrier and nuclear transport system
• An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system.
• At the cutting edge: applications and perspectives of laser nanosurgery in cell biology.
• Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission.
• Dynamic and reversible restructuring of the ER induced by PDMP in cultured cells.
• ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.
• Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples
• Following the fate in vivo of COPI vesicles generated in vitro.
• GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.
• Golgi depletion from living cells with laser nanosurgery.
• High-precision targeting workflow for volume electron microscopy
• Identifying long-range synaptic inputs using genetically encoded labels and volume electron microscopy
• Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphologies
• Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes.
• Mesopolysaccharides: The extracellular surface layer of visceral organs
• Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis.
• Positive feedback between Golgi membranes, microtubules and ER exit sites directs de novo biogenesis of the Golgi.
• Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.
• Profiling cellular diversity in sponges informs animal cell type and nervous system evolution
• Single cell polarity in liquid phase facilitates tumour metastasis.
• Spatial control of nucleoporin assembly by Fragile X-related proteins
• Targeted Ablation Using Laser Nanosurgery.
• Transmembrane domain-dependent partitioning of membrane proteins within the endoplasmic reticulum.
• Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells.
• Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells
• Ultrastructural Characterization of Zika Virus Replication Factories