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• A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila
• A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.
• CRISPRAnalyzeR: Interactive analysis, annotation and documentation of pooled CRISPR screens
• Context-dependent genetic interactions in cancer.
• Detection of mutational patterns in cell-free DNA of colorectal cancer by custom amplicon sequencing.
• Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library.
• High-speed fluorescence image–enabled cell sorting
• Lineage specific core-regulatory circuits determine gene essentiality in cancer cells
• MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
• Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.
• Patient-derived gene and protein expression signatures of NGLY1 deficiency
• Phenotype databases for genetic screens in human cells.
• Pooled CRISPR screening at high sensitivity with an empirically designed sgRNA library
• The drug-induced phenotypic landscape of colorectal cancer organoids
• Toward an integrated map of genetic interactions in cancer cells.
• β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.