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• BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo.
• Fate-Patterning of 2D Gastruloids and Ectodermal Colonies Using Micropatterned Human Pluripotent Stem Cells.
• Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation.
• Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.
• Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells