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• Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution.
• Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
• Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor.
• Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.
• Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.
• Conjugative transposition of the vancomycin resistance carrying Tn1549 : enzymatic requirements and target site preferences
• Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc.
• Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus.
• DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans.
• Effects of stably incorporated iron on protein phosphatase‐1 structure and activity
• Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
• Helicobacter Pylori's plasticity zones are novel transposable elements.
• In vitro reconstitution of a single-stranded transposition mechanism of IS608.
• Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq.
• Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection.
• Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
• Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers.
• Resetting the site: redirecting integration of an insertion sequence in a predictable way.
• Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r.
• Sequence analysis allows functional annotation of tyrosine recombinases in prokaryotic genomes
• Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes
• Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
• Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase.
• Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending
• Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.
• Synthesis and stereochemistry of dispiro substituted pyridazines: application of ellipticity-absorbance ratio spectra for proving enantiomeric relationship by HPLC-CD/UV detection.
• Targeting IS608 transposon integration to highly specific sequences by structure-based transposon engineering
• The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans
• Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C ‐Terminal Phosphorylation
• Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance
• dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency.