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• 3' end mRNA processing: molecular mechanisms and implications for health and disease.
• 3' end processing of the prothrombin mRNA in thrombophilia.
• 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
• A Red Carpet for Iron Metabolism.
• A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.
• A brave new world of RNA-binding proteins.
• A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.
• A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
• A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA.
• A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
• A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
• A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila.
• A genetically encoded diazirine analogue for RNA-protein photocrosslinking.
• A model for the structure and functions of iron-responsive elements.
• A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.
• A new era for the RNA world. Conference: RNA 2000.
• A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.
• A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.
• A perfect message: RNA surveillance and nonsense-mediated decay.
• A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells.
• A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA).
• A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo.
• A versatile assay for RNA-binding proteins in living cells.
• Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function.
• Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay.
• Activation of iron regulatory protein-1 by oxidative stress in vitro.
• Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).
• An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
• An efficient factor-depleted mammalian in vitro translation system.
• An interview with Matthias Hentze.
• Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
• Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.
• Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation.
• Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro.
• Balancing acts: molecular control of mammalian iron metabolism.
• Binary specification of nonsense codons by splicing and cytoplasmic translation.
• Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.
• Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.
• Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
• Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1.
• Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism.
• Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.
• Characterization of the African swine fever virus decapping enzyme during infection.
• Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.
• Circular RNAs: splicing's enigma variations.
• Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.
• Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.
• Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.
• Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.
• Comprehensive Identification of RNA-Binding Domains in Human Cells.
• Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.
• Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production.
• Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships.
• Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.
• Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation.
• Coordination of cellular iron metabolism by post-transcriptional gene regulation.
• Core cross-linked polymeric micelles for specific iron delivery: inducing sterile inflammation in macrophages.
• Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
• Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells.
• Determination of mRNA fate by different RNA polymerase II promoters.
• Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
• Disassembly of exon junction complexes by PYM.
• Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture
• Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.
• Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.
• Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA.
• Dual function of UPF3B in early and late translation termination.
• Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast.
• EMBO Molecular Medicine: Conquering new frontiers.
• ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
• Elisa Izaurralde 1959-2018.
• Enhanced degradation of cathepsin D synthesized in the presence of the threonine analog beta-hydroxynorvaline.
• Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP.
• Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?
• Erratum to: Insights into the design and interpretation of iCLIP experiments.
• Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation.
• Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
• Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.
• Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.
• FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.
• Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.
• Fertility facts: male and female germ cell development requires translational control by CPEB.
• Finding the hairpin in the haystack: searching for RNA motifs.
• From cis-regulatory elements to complex RNPs and back.
• From factors to mechanisms: translation and translational control in eukaryotes.
• From transcript to protein.
• Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
• Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.
• Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides.
• Genetics. IRES unplugged.
• Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
• Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila
• Hfe acts in hepatocytes to prevent hemochromatosis.
• Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.
• Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
• Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding.
• IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.
• IRP1 activation by extracellular oxidative stress in the perfused rat liver.
• IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice.
• Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
• Identification of RNA-binding domains of RNA-binding proteins in cultured cells on a system-wide scale with RBDmap.
• Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.
• Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays.
• Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
• Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.
• In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings
• In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.
• Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress.
• Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia.
• Influence of altered transcription on the translational control of human ferritin expression.
• Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
• Insights into the design and interpretation of iCLIP experiments.
• Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.
• Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
• Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay.
• Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.
• Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.
• Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse.
• Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
• Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.
• Iron regulates nitric oxide synthase activity by controlling nuclear transcription.
• Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.
• Iron regulatory factor--the conductor of cellular iron regulation.
• Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
• Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.
• Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria.
• Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.
• Iron regulatory proteins control a mucosal block to intestinal iron absorption.
• Iron regulatory proteins secure mitochondrial iron sufficiency and function.
• Iron-dependent regulation of the divalent metal ion transporter.
• Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.
• Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans.
• Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.
• Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
• Iron-sulfur clusters and oxidant stress responses.
• Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1.
• Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
• Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting.
• Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining.
• Making sense of nonsense.
• Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.
• Mechanism of riboregulation of p62 protein oligomerisation by vault RNA1-1 in selective autophagy
• Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame.
• Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins.
• Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
• Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?
• Molecular analysis of iron overload in beta2-microglobulin-deficient mice.
• Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
• Molecular mechanisms of translational control.
• Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.
• NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.
• NMD: RNA biology meets human genetic medicine.
• New ways of initiating translation in eukaryotes.
• Nitric oxide and the post-transcriptional control of cellular iron traffic.
• Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.
• Nonsense-mediated decay approaches the clinic.
• Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.
• Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm.
• Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
• Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
• PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.
• Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.
• Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
• Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins.
• Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.
• Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system.
• Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins
• Poly(A)-tail-promoted translation in yeast: implications for translational control.
• Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function.
• Protein synthesis. Believe it or not-translation in the nucleus.
• Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.
• Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay
• RNA regulates Glycolysis and Embryonic Stem Cell Differentiation via Enolase 1
• RNA-binding proteins in Mendelian disease.
• RNA-binding proteins in human genetic disease
• Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion.
• Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch.
• Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches
• Regulation of protein synthesis by mRNA structure.
• Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
• Relationships and distinctions in iron-regulatory networks responding to interrelated signals.
• Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload.
• Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation
• SIREs: searching for iron-responsive elements.
• SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.
• STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.
• Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.
• Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation.
• Silica-based solid-phase extraction of cross-linked nucleic acid–bound proteins
• Specific RNP capture with antisense LNA/DNA mixmers.
• Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.
• Splicing factors stimulate polyadenylation via USEs at non-canonical 3 ' end formation signals
• Starting at the beginning, middle, and end: translation initiation in eukaryotes.
• Studying translational control in Drosophila cell-free systems.
• System-wide identification of RNA-binding proteins by interactome capture.
• Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches
• Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.
• Systems analysis of iron metabolism: the network of iron pools and fluxes.
• Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides.
• Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.
• Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.
• Tethering assays to investigate nonsense-mediated mRNA decay activating proteins.
• The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease.
• The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
• The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
• The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays.
• The REM phase of gene regulation.
• The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance
• The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
• The RNA-binding protein landscapes differ between mammalian organs and cultured cells
• The RNA-binding protein repertoire of embryonic stem cells.
• The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.
• The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA.
• The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
• The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway.
• The actin-binding protein profilin 2 is a novel regulator of iron homeostasis
• The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
• The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
• The human intronless melanocortin 4-receptor gene is NMD insensitive.
• The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast.
• The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.
• The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.
• The molecular circuitry regulating the switch between iron deficiency and overload in mice.
• The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing.
• The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.
• The role of ABCE1 in eukaryotic posttermination ribosomal recycling.
• The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).
• The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation.
• Translation driven by an eIF4G core domain in vivo.
• Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.
• Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent.
• Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?
• Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail.
• Translational control via protein-regulated upstream open reading frames.
• Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.
• Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.
• Translational regulation: versatile mechanisms for metabolic and developmental control.
• Translational repression assay procedure: a method to study RNA-protein interactions in yeast.
• Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae.
• Two to tango: regulation of Mammalian iron metabolism.
• Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.
• Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
• Using the lambdaN peptide to tether proteins to RNAs.
• Vault RNA emerges as a regulator of selective autophagy
• Vault RNA1–1 riboregulates the autophagic function of p62 by binding to lysine 7 and arginine 21, both of which are critical for p62 oligomerization
• Y14 and hUpf3b form an NMD-activating complex.
• [Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]
• c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
• eIF4G: a multipurpose ribosome adapter?
• mRNA 3'end processing: A tale of the tail reaches the clinic.
• mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.
• miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes.
• miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes.
• microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.
• p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
• ‘High vault-age’: non-coding RNA control of autophagy