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• A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair.
• A Guardian of the Heartbeat.
• A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field.
• A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo.
• A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors.
• A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locus.
• A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration.
• A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.
• A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells.
• A transgene target for positional regulators marks early rostrocaudal specification of myogenic lineages.
• A tribute to Sir John Gurdon.
• Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction.
• Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function.
• Activation of a muscle-specific enhancer by the Ski proto-oncogene.
• Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues.
• All at the tip of a needle
• An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation.
• An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile.
• An atypical role for the myeloid receptor Mincle in central nervous system injury.
• Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification.
• Analysis of cardiac myocyte biology in transgenic mice: a protocol for preparation of neonatal mouse cardiac myocyte cultures.
• Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells.
• Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes.
• BK viral enhancer element and a human cellular homolog.
• Beyond knockouts: cre resources for conditional mutagenesis.
• CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.
• Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.
• Canagliflozin extends life span in genetically heterogeneous male but not female mice.
• Cardiac Cellularity is Dependent upon Biological Sex and is Regulated by Gonadal Hormones.
• Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver.
• Cardiac mapping and stem cell delivery for the damaged myocardium.
• Cardiac regeneration: All work and no repair?
• Cardiac regeneration: epicardial mediated repair.
• Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction.
• Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
• Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
• Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging.
• Chasing the recipe for a pro-regenerative immune system.
• Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels.
• Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
• Conference of the International Society of Differentiation
• Congenital valvular defects associated with deleterious mutations in the PLD1 gene.
• Cre recombinase resources for conditional mouse mutagenesis.
• Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations.
• CreZOO--the European virtual repository of Cre and other targeted conditional driver strains.
• DNA and the genetic code.
• Derive and conquer: sourcing and differentiating stem cells for therapeutic applications.
• Detection of messenger RNA by in situ hybridization.
• Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.
• Different modes of hypertrophy in skeletal muscle fibers.
• Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus.
• Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
• Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice
• Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart.
• E-peptides control bioavailability of IGF-1.
• Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation.
• Editorial overview
• Effects of IGF‐1 isoforms on muscle growth and sarcopenia
• Enhancing repair of the mammalian heart.
• EuroPhenome: a repository for high-throughput mouse phenotyping data.
• Expression of follistatin-related genes is altered in heart failure.
• Extracellular matrix considerations for scar-free repair and regeneration: insights from regenerative diversity among vertebrates.
• Finding and sharing: new approaches to registries of databases and services for the biomedical sciences.
• Fine structure of a gene--DNA sequencing.
• Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes.
• From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation.
• Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.
• Gene therapy for cardiac cachexia?
• Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafish.
• Growth factor enhancement of cardiac regeneration.
• Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape.
• Helping the heart to heal with stem cells.
• High hopes for the heart.
• High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy.
• Homeobox genes and muscle patterning.
• Human hepatocytes in mice receiving pre-immune injection with human cord blood cells.
• Humanizing the mdx mouse model of DMD: the long and the short of it.
• IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.
• IGF-1, inflammation and stem cells: interactions during muscle regeneration.
• IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines.
• Identification of novel peptide hormones in the human proteome by hidden Markov model screening.
• Identification of regulatory elements of cloned genes with functional assays.
• Immune response to stem cells and strategies to induce tolerance.
• Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.
• In search of a wide-angle perspective.
• In search of perverse polymorphisms.
• Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea.
• Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer.
• Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation.
• Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease.
• Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice.
• Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia.
• Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
• Intramyocardial cell delivery: observations in murine hearts.
• Isolation and analysis of single cells from the mouse heart.
• Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines.
• Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle.
• Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction.
• Machinations of the marrow.
• Macrophages are required for adult salamander limb regeneration.
• Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation.
• Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I.
• Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans.
• Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.
• MicroRNA-29 in aortic dilation: implications for aneurysm formation.
• Microarray profiling to analyse adult cardiac fibroblast identity.
• Mitral valve disease--morphology and mechanisms.
• Models for financial sustainability of biological databases and resources.
• Modular elements of the MLC 1f/3f locus confer fiber-specific transcription regulation in transgenic mice.
• Molecular control of muscle diversity and plasticity.
• Molecular medicine. Recognizing DNA.
• Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization.
• Mouse Resource Browser--a database of mouse databases.
• Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice.
• Muscle cell differentiation.
• Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model.
• Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting.
• Muscle-specific expression of human insulin receptor in transgenic mice.
• Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice.
• Myocardial regenerative properties of macrophage populations and stem cells.
• Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice.
• NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases.
• Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition.
• One small step for muscle: a new micropeptide regulates performance.
• Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice.
• Paired MyoD-binding sites regulate myosin light chain gene expression.
• Phenostat: visualization and statistical tool for analysis of phenotyping data.
• Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.
• Post-publication sharing of data and tools.
• Preparing the ground for tissue regeneration: from mechanism to therapy.
• Progressive replacement of embryo-derived cardiac macrophages with age.
• Proliferation precedes differentiation in IGF-I-stimulated myogenesis.
• Prometheus's vulture and the stem-cell promise.
• Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling.
• Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injury.
• ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program.
• Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle.
• Regenerative medicine: the challenge of translation. Editorial.
• Regulation of a muscle-specific transgene by persistent expression of Hox genes in postnatal murine limb muscle.
• Regulation of a muscle-specific transgene by retinoic acid.
• Regulation of gene expression.
• Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.
• Research funding. Sustaining the data and bioresource commons.
• Retinoid signaling and cardiac anteroposterior segmentation.
• Revealing new mouse epicardial cell markers through transcriptomics.
• Revisiting Cardiac Cellular Composition.
• Revisiting calcineurin and human heart failure.
• Rostrocaudal gradient of transgene expression in adult skeletal muscle.
• Scar-free wound healing and regeneration in amphibians: immunological influences on regenerative success.
• Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart.
• Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis.
• Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice.
• Single allele mutations at the heart of congenital disease.
• Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart.
• SirT1 in muscle physiology and disease: lessons from mouse models.
• Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.
• Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation.
• Stalking the gene--DNA libraries.
• Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1.
• Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.
• Systems approaches in integrative cardiac biology: illustrations from cardiac heterocellular signalling studies.
• Taking stock of our models: the function and future of stock centres.
• Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration.
• Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation.
• Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice.
• Teasing the Immune System to Repair the Heart
• The European dimension for the mouse genome mutagenesis program.
• The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).
• The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?
• The cardiac fibroblast: Origin, identity and role in homeostasis and disease.
• The critical role of Insulin-like Growth Factor-1 isoforms in the physiopathology of skeletal muscle
• The future of regenerative therapy in patients with chronic heart failure.
• The interstitium in cardiac repair: role of the immune-stromal cell interplay.
• The mammalian gene function resource: the International Knockout Mouse Consortium.
• The mouse ascending: perspectives for human-disease models.
• The myosin light chain enhancer and the skeletal actin promoter share a binding site for factors involved in muscle-specific gene expression.
• The neonate versus adult mammalian immune system in cardiac repair and regeneration.
• The neuroprotective effects of a locally acting IGF-1 isoform.
• The role of stem cells in skeletal and cardiac muscle repair.
• The structure and evolution of the two nonallelic rat preproinsulin genes.
• The structure and transcription of four linked rabbit beta-like globin genes.
• The structure of rat preproinsulin genes.
• Tools of the trade--recombinant DNA.
• Toward Regeneration of the Heart: Bioengineering Strategies for Immunomodulation.
• Transgenic analysis of cardiac and skeletal myogenesis.
• Transgenic mouse models of muscle aging.
• Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction.
• Unravelling the endovascular microenvironment by optical coherence tomography.
• Utilising the resources of the International Knockout Mouse Consortium: the Australian experience.
• VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery.
• Variable outcomes of human heart attack recapitulated in genetically diverse mice.
• Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways.
• View from the heart: cardiac fibroblasts in development, scarring and regeneration.
• Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.
• Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension.
• mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.