article

• A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
• ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
• Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: Interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides
• Anomalous and normal diffusion of proteins and lipids in crowded lipid membranes
• Bifunctional avidin with covalently modifiable ligand binding site
• Connection between absorption properties and conformational changes in Deinococcus radiodurans phytochrome
• Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride)
• Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
• JAK2S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2V617F− MPNs
• Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.
• Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses
• Membrane proteins diffuse as dynamic complexes with lipids
• Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
• New insights into the structure and function of the pseudokinase domain in JAK2
• Nucleotide-binding mechanisms in pseudokinases
• Structural and functional characterization of the JH2 pseudokinase domain of JAK family tyrosine kinase 2 (TYK2)
• The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains
• The regulation of JAKs in cytokine signaling and its breakdown in disease.