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• Activation of the TGFβ pathway impairs endothelial to haematopoietic transition
• Discovery of a new path for red blood cell generation in the mouse embryo
• GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
• Iron deficiency affects early stages of embryonic hematopoiesis but not the endothelial to hematopoietic transition
• Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition
• Operation of a TCA cycle subnetwork in the mammalian nucleus
• Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium
• Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium
• Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endothelium
• Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
• Single-cell transcriptomics identifies CD44 as a new marker and regulator of haematopoietic stem cells development
• Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis