selected publications
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article
- A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
- A refined reaction-diffusion model of tau-microtubule dynamics and its application in FDAP analysis
- Alkylene-bridged viologen dendrimers: Versatile cell delivery tools with biosensing properties
- Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation
- Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization
- Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D
- Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport
- Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration
- Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice
- Chapter 2 Live‐Cell Imaging in the Study of Neurodegeneration
- Chronic Presence of Oligomeric Aβ Differentially Modulates Spine Parameters in the Hippocampus and Cortex of Mice With Low APP Transgene Expression
- Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice
- Contact with astroglial membranes induces axonal and dendritic growth of human CNS model neurons and affects the distribution of the growth-associated proteins MAP1b and GAP43
- Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau
- Cytoskeletal mechanisms of axon outgrowth and pathfinding
- Cytoskeletal mechanisms of neuronal degeneration
- Cytoskeletal mechanisms of neuronal morphogenesis
- DMSO modulates CNS function in a preclinical Alzheimer's disease model
- Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons. Evidence that gravin provides a dynamic platform for the localization of kinases during neuronal development
- Differential interactions of MAP2, tau and MAP5 during axogenesis in culture
- Divergent pathways mediate spine alterations and cell death induced by amyloid-β, wild-type tau, and R406W tau
- Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons
- Evaluation and Elucidation of DNA-Containing Viologen Dendrimer Complex Formation
- Functional Interactions of Tau and their Relevance for Alzheimers Disease
- Functions and malfunctions of the tau proteins
- Funktionen des Zytoskeletts bei der Entwicklung von Nervenzellen
- Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells)
- High-resolution imaging and evaluation of spines in organotypic hippocampal slice cultures
- Highlight: The physiology and dynamics of cellular microcompartments
- Histology and histochemistry of axonal growth
- Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
- Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor
- Identification of Nucleoside Analogs as Inducers of Neuronal Differentiation in a Human Reporter Cell Line and Adult Stem Cells
- Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway
- Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
- Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
- Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43
- Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-β in cultured cortical neurons: Evidence that tau phosphorylation is the limiting factor in amyloid-β-induced cell death
- Live cell imaging of cytoskeletal dynamics in neurons using fluorescence photoactivation
- Machine learning to evaluate neuron density in brain sections
- Mechanisms of neurodegenerative diseases: Insights from live cell imaging
- Meet Our Editorial Board Member
- Microcompartments in the Drosophila heart and the mammalian brain: general features and common principles
- Microtubule Binding and Trapping at the Tip of Neurites Regulate Tau Motion in Living Neurons
- Microtubule Dynamics in Neuronal Development, Plasticity, and Neurodegeneration
- Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection
- Microtubulebundling studies revisited: is there a role for MAPs?
- Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies
- Monitoring cytoskeletal dynamics in living neurons using fluorescence photoactivation
- Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau
- NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss
- Nanocores and Liquid Droplets: Single-Molecule Microscopy of Neuronal Stress Granule Components
- Neurotrophins Differentially Regulate the Survival and Morphological Complexity of Human CNS Model Neurons
- O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)
- Orientation, assembly, and stability of microtubule bundles induced by a fragment of tau protein
- Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein
- Presence of a carboxy-Terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau's interaction with microtubules in axon-like processes
- Purification of MINUS: A negative regulator of microtubule nucleation in a variety of organisms
- RNA protein granules modulate tau isoform expression and induce neuronal sprouting
- Reconstruction and morphometric analysis of hippocampal neurons from mice expressing fluorescent proteins
- Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: A mechanistic distinct event from other neurodegenerative processes
- Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease
- Ribosomal localization of the mRNA in the 30S initiation complex as revealed by UV crosslinking
- Ribosome-mRNA contact sites at different stages of translation initiation as revealed by cross-linking of model mRNAs
- Shearlet analysis of confocal laser-scanning microscopy images to extract morphological features of neurons
- Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: The humanization of yeast cells
- Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules
- Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons
- Special issue on ‘Cytoskeletal proteins in health and neurodegenerative disease’
- Stabilization of hyperdynamic microtubules is neuroprotective in amyotrophic lateral sclerosis
- Structural and Functional Implications of Tau Hyperphosphorylation: Information from Phosphorylation-Mimicking Mutated Tau Proteins†
- Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies
- Targeting microtubules in axonal re- and degeneration (Commentary on Li et al. ())
- Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease
- Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices
- Tau alteration and neuronal degeneration in tauopathies: Mechanisms and models
- Tau and α-synuclein shape microtubule organization and microtubule-dependent transport in neuronal dendrites
- The Balance Between τ Protein's Microtubule Growth and Nucleation Activities: Implications for the Formation of Axonal Microtubules
- The Evolution of Tau Phosphorylation and Interactions
- The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome
- The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner
- The microtubule skeleton and the evolution of neuronal complexity in vertebrates
- The tau proteins in neuronal growth and development.
- The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules
- Thin, stubby or mushroom: Spine pathology in alzheimer's disease
- Triple mammalian/yeast/bacterial shuttle vectors for single and combined Lentivirus- and Sindbis virus-mediated infections of neurons