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• A Novel Amyloid Designable Scaffold and Potential Inhibitor Inspired by GAIIG of Amyloid Beta and the HIV-1 V3 loop.
• A comparative anatomy of protein crystals: lessons from the automatic processing of 56 000 samples
• A comparative anatomy of protein crystals: lessons from the automatic processing of 56,000 samples
• A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria
• A molecular mechanism for transthyretin amyloidogenesis
• A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model
• A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma
• A spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinase
• Assessing the Influence of Mutation on GTPase Transition States by using X-ray Crystallography, 19 F NMR, and DFT Approaches.
• Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF3^- rather than by phosphoranes
• Automated data collection based on RoboDiff at the ESRF beamline MASSIF-1
• Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF
• Automation and Experience of Controlled Crystal Dehydration: Results from the European Synchrotron HC1 Collaboration
• Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.
• Computational Design of Amyloid Self-Assembling Peptides Bearing Aromatic Residues and the Cell Adhesive Motif Arg-Gly-Asp
• Conformational dynamics in phosphoglycerate kinase, an open and shut case?
• Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin
• Cross-reactive SARS-CoV-2 neutralizing antibodies from deep mining of early patient responses.
• Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from schizosaccharomyces pombe
• CrystalDirect-To-Beam: Opening the shortest path from crystal to data
• Diffraction cartography: Applying microbeams to macromolecular crystallography sample evaluation and data collection
• Direct cryocooling of naked crystals: Are cryoprotection agents always necessary?
• Finding order in chaos – nanocrystals in amorphous protein gels
• FlexED8: the first member of a fast and flexible sample-changer family for macromolecular crystallography
• Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules.
• Fully automatic characterization and data collection from crystals of biological macromolecules.
• Fully automatic macromolecular crystallography: the impact of MASSIF-1 on the optimum acquisition and quality of data
• Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 Å resolution
• How azide inhibits ATP hydrolysis by the F-ATPases
• ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments.
• Improving diffraction by humidity control: A novel device compatible with X-ray beamlines
• Increasing the diffraction limit and internal order of a membrane protein crystal by dehydration
• Inducing phase changes in crystals of macromolecules: Status and perspectives for controlled crystal dehydration
• Interaction of human 3-phosphoglycerate kinase with its two substrates: Is substrate antagonism a kinetic advantage?
• Le rayonnement synchrotron : comprendre la relation structure-fonction des macromolecules biologiques
• Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation.
• MASSIF-1: A beamline dedicated to the fully automatic characterization and data collection from crystals of biological macromolecules
• MXCuBE2: the dawn of MXCuBE Collaboration.
• Measurement of the equilibrium relative humidity for common precipitant concentrations: Facilitating controlled dehydration experiments
• Measurement of the intrinsic variability within protein crystals: implications for sample-evaluation and data-collection strategies.
• MgF3^- and α-galactose 1-phosphate in the active site of β-phosphoglucomutase form a transition state analogue of phosphoryl transfer
• Multi-position data collection and dynamic beam sizing: recent improvements to the automatic data-collection algorithms on MASSIF-1
• MxCuBE: A synchrotron beamline control environment customized for macromolecular crystallography experiments
• Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate
• New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans.
• Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy
• Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans.
• QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing.
• Raoult's law revisited: accurately predicting equilibrium relative humidity points for humidity control experiments.
• Recent progress in robot-based systems for crystallography and their contribution to drug discovery
• Reflections on biocatalysis involving phosphorus.
• Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F1-ATPase by controlled dehydration
• RoboDiff: combining a sample changer and goniometer for highly automated macromolecular crystallography experiments.
• Self-assembled amyloid peptides with Arg-Gly-Asp (RGD) motifs as scaffolds for tissue engineering
• Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.
• Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport.
• Structural and functional comparison of fumarylacetoacetate domain containing protein 1 (FAHD1) in human and mouse.
• Structural basis for Scc3-dependent cohesin recruitment to chromatin
• Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.
• Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
• Structural basis for specific recognition of pre-snRNA by Gemin5.
• Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.
• Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus.
• Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.
• Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
• The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1.
• The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility
• The sweet quartet: Binding of fucose to the norovirus capsid.
• The upgrade programme for the structural biology beamlines at the European synchrotron Radiation Facility-High throughput sample evaluation and automation
• The use of workflows in the design and implementation of complex experiments in macromolecular crystallography
• Towards a compact and precise sample holder for macromolecular crystallography.
• Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis
• Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening
• Why did Nature select phosphate for its dominant roles in biology?
• van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture
• α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.