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• Germ cell sex determination in mammals.
• Inverted light-sheet microscope for imaging mouse pre-implantation development.
• Meiosis and retrotransposon silencing during germ cell development in mice.
• Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells.
• Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.
• Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.
• The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.
• Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.