selected publications
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article
- 3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex
- A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase.
- A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.
- A call for public archives for biological image data.
- A cell-based model system links chromothripsis with hyperploidy.
- A contractile nuclear actin network drives chromosome congression in oocytes.
- A fractal model for nuclear organization: current evidence and biological implications.
- A new model for asymmetric spindle positioning in mouse oocytes.
- A new model for nuclear envelope breakdown.
- A proposal for validation of antibodies.
- A protocol for the systematic and quantitative measurement of protein-lipid interactions using the liposome-microarray-based assay.
- A quantitative liposome microarray to systematically characterize protein-lipid interactions
- A quantitative map of human Condensins provides new insights into mitotic chromosome architecture
- A quantitative map of human Condensins provides new insights into mitotic chromosome architecture
- A quantitative map of nuclear pore assembly reveals two distinct mechanisms
- A system for imaging the regulatory noncoding Xist RNA in living mouse embryonic stem cells.
- ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.
- Absolute quantification of cohesin, CTCF and their regulators in human cells
- Absolute quantification of cohesin, CTCF and their regulators in human cells
- An RNAi screening platform to identify secretion machinery in mammalian cells.
- An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.
- An experimental and computational framework to build a dynamic protein atlas of human cell division
- Assessment of 3D MINFLUX data for quantitative structural biology in cells revisited
- Author Correction: Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.
- Automatic analysis of dividing cells in live cell movies to detect mitotic delays and correlate phenotypes in time.
- Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging.
- Automatic identification of subcellular phenotypes on human cell arrays.
- Automatic quantification of microtubule dynamics enables RNAi-screening of new mitotic spindle regulators.
- Automatic real-time three-dimensional cell tracking by fluorescence microscopy.
- CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin
- Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions.
- CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging.
- Chemogenetic Control of Nanobodies
- Chemogenetic Control of Nanobodies.
- ChromoTrace: Computational reconstruction of 3D chromosome configurations for super-resolution microscopy.
- ChromoTrace: Reconstruction of 3D Chromosome Configurations by Super-Resolution Microscopy
- Chromophore-assisted laser inactivation of alpha- and gamma-tubulin SNAP-tag fusion proteins inside living cells.
- Chromosomal association of Ran during meiotic and mitotic divisions.
- Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells.
- Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes.
- Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
- Correction: Correlative live and super-resolution imaging reveals the dynamic structure of replication domains.
- Correlative live and super-resolution imaging reveals the dynamic structure of replication domains
- Correlative live and super-resolution imaging reveals the dynamic structure of replication domains
- Crowded chromatin is not sufficient for heterochromatin formation and not required for its maintenance.
- Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling.
- Determining cellular CTCF and cohesin abundances to constrain 3D genome models
- Determining cellular CTCF and cohesin abundances to constrain 3D genome models
- Direct Visualization of Single Nuclear Pore Complex Proteins Using Genetically‐Encoded Probes for DNA‐PAINT
- Direct Visualization of Single Nuclear Pore Complex Proteins Using Genetically‐Encoded Probes for DNA‐PAINT
- Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT
- Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins.
- Distinct functions of condensin I and II in mitotic chromosome assembly.
- Dual spindle formation in zygotes keeps parental genomes apart in early mammalian embryos
- Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes
- Dual-colour imaging with GFP variants.
- Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos
- Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay.
- Dynamics and mobility of nuclear envelope proteins in interphase and mitotic cells revealed by green fluorescent protein chimeras.
- Dynamics and retention of misfolded proteins in native ER membranes.
- Dynamics of chromosome positioning during the cell cycle.
- Dynamics of nuclear pore complex organization through the cell cycle.
- EGF-induced centrosome separation promotes mitotic progression and cell survival.
- EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
- Experimental and computational framework for a dynamic protein atlas of human cell division.
- FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35.
- Fast, robust and precise 3D localization for arbitrary point spread functions
- Fluorescence perturbation techniques to study mobility and molecular dynamics of proteins in live cells: FRAP, photoactivation, photoconversion, and FLIP.
- Formation of the nuclear envelope permeability barrier studied by sequential photoswitching and flux analysis.
- Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells.
- GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
- Gain of CTCF-Anchored Chromatin Loops Marks the Exit from Naive Pluripotency.
- Generation and validation of homozygous fluorescent knock-in cells using CRISPR/Cas9 genome editing
- Generation and validation of homozygous fluorescent knock-in cells using CRISPR–Cas9 genome editing
- Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.
- Global chromosome positions are transmitted through mitosis in mammalian cells.
- Golgi membranes are absorbed into and reemerge from the ER during mitosis.
- High-throughput RNAi screening by time-lapse imaging of live human cells.
- High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.
- High-throughput fluorescence microscopy for systems biology.
- High-throughput microscopy using live mammalian cells.
- Histone H3 phosphorylation during Xenopus oocyte maturation: regulation by the MAP kinase/p90Rsk pathway and uncoupling from DNA condensation.
- Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei.
- Imaging the assembly, structure, and function of the nuclear pore inside cells.
- Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.
- Intracellular transport by an anchored homogeneously contracting F-actin meshwork.
- Inverted light-sheet microscope for imaging mouse pre-implantation development.
- Ki-67 acts as a biological surfactant to disperse mitotic chromosomes.
- Kinetic analysis of secretory protein traffic and characterization of golgi to plasma membrane transport intermediates in living cells.
- LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.
- LambdaN-GFP: an RNA reporter system for live-cell imaging.
- LifeTime and improving European healthcare through cell-based interceptive medicine.
- Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains.
- Live imaging and modeling of inner nuclear membrane targeting reveals its molecular requirements in mammalian cells.
- Live imaging of cell division in preimplantation mouse embryos using inverted light-sheet microscopy.
- Live imaging of single nuclear pores reveals unique assembly kinetics and mechanism in interphase.
- Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.
- MAP1S controls microtubule stability throughout the cell cycle in human cells.
- MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells
- MINFLUX nanoscopy delivers multicolor nanometer 3D-resolution in (living) cells
- Mapping the dynamic organization of the nuclear pore complex inside single living cells.
- Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase.
- Measuring structural dynamics of chromosomes in living cells by fluorescence microscopy.
- Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.
- Mechanisms of nuclear pore complex assembly – two different ways of building one molecular machine
- Micropilot: automation of fluorescence microscopy-based imaging for systems biology.
- Minimizing the risk of reporting false positives in large-scale RNAi screens.
- Mitotic lamin disassembly is triggered by lipid-mediated signaling.
- Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
- Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin.
- Monitoring the permeability of the nuclear envelope during the cell cycle.
- Multiple Requirements of PLK1 during Mouse Oocyte Maturation.
- Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells.
- Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division.
- Mysteries in embryonic development: How can errors arise so frequently at the beginning of mammalian life?
- Non-rodent mammalian zygotes assemble dual spindles despite the presence of paternal centrosomes
- NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules.
- NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization.
- Nuclear actin: a lack of export allows formation of filaments.
- Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes.
- Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina.
- Nuclear envelope dynamics in oocytes: from germinal vesicle breakdown to mitosis.
- Nuclear envelope.
- Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.
- Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis.
- Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope
- Nuclear pore complex assembly through the cell cycle: regulation and membrane organization.
- Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells.
- Nuclear pore scaffold structure analyzed by super-resolution microscopy and particle averaging.
- Nuclear pores as versatile reference standards for quantitative superresolution microscopy
- Nuclear pores as versatile reference standards for quantitative superresolution microscopy
- Nucleocytoplasmic transport: diffusion channel or phase transition?
- Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1.
- Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.
- Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases.
- Photoactivation of silicon rhodamines via a light-induced protonation
- Photoactivation of silicon rhodamines via a light-induced protonation
- Postmitotic nuclear pore assembly proceeds by radial dilation of small ER membrane openings
- Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings
- Profiling DNA damage response following mitotic perturbations
- Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.
- Publisher Correction: Nuclear pores as versatile reference standards for quantitative superresolution microscopy
- Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells.
- Quantitative live and super-resolution microscopy of mitotic chromosomes.
- Quantitative mapping of fluorescently tagged cellular proteins using FCS-calibrated four dimensional imaging
- Quantitative mapping of fluorescently tagged cellular proteins using FCS-calibrated four-dimensional imaging
- REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology.
- RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
- RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export
- Rapid generation of homozygous fluorescent knock-in human cells using CRISPR/Cas9 genome editing and validation by automated imaging and digital PCR screening
- Real-Time Imaging of a Single Gene Reveals Transcription-Initiated Local Confinement.
- Real-time 3D single-molecule localization using experimental point spread functions
- Real-time chromatin dynamics at the single gene level during transcription activation
- Regulation of sister chromatid cohesion between chromosome arms.
- Remodelling the walls of the nucleus.
- Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
- Retrograde transport of Golgi-localized proteins to the ER.
- Reverse transfection on cell arrays for high content screening microscopy.
- Ribonucleoprotein-dependent localization of the yeast class V myosin Myo4p.
- Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.
- SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
- Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.
- Simulating structurally variable Nuclear Pore Complexes for Microscopy
- Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.
- Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit.
- Sun1 forms immobile macromolecular assemblies at the nuclear envelope.
- Super-Resolution Spatial Proximity Detection with Proximity-PAINT.
- Systematic analysis of human protein complexes identifies chromosome segregation proteins.
- Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells.
- The 4D nucleome project.
- The cellular microscopy phenotype ontology.
- The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.
- The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.
- The quantitative proteome of a human cell line.
- The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.
- The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.
- The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum.
- Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex.
- Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
- Visualization of image data from cells to organisms.
- Visualization of loop extrusion by DNA nanoscale tracing in single human cells
- Wapl is an essential regulator of chromatin structure and chromosome segregation.
- Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates.
- ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.
- iNEXT: a European facility network to stimulate translational structural biology.