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• A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling.
• A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways
• A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription.
• A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking.
• A role for eisosomes in maintenance of plasma membrane phosphoinositide levels.
• A systematic approach to identify recycling endocytic cargo depending on the GARP complex.
• A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function
• AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering
• Analysis of Organelle Dynamics by Quantitative Mass Spectrometry Based Proteomics
• Comparing cellular proteomes by mass spectrometry.
• Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast.
• Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis
• Das Rätsel der Sphinx — Mechanismen der zellulären Sphingolipidhomöostase
• Deep and highly sensitive proteome coverage by LC-MS/MS without prefractionation.
• Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism
• Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex
• Global analysis of the yeast osmotic stress response by quantitative proteomics.
• Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe.
• Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor
• Mechanisms of Lipid Sorting in the Endosomal Pathway
• Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
• Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation.
• Phosphorylation of the GARP Subunit Vps53 by Snf1 Leads to the Formation of a Golgi – Mitochondria Contact Site (GoMiCS) in Yeast
• Pkh-kinases control eisosome assembly and organization.
• Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.
• QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.
• Rab GTPase Function in Endosome and Lysosome Biogenesis.
• Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.
• Seg1 controls eisosome assembly and shape.
• Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.
• Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.
• The GARP complex is required for cellular sphingolipid homeostasis.
• The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity
• The role of very long chain fatty acids in yeast physiology and human diseases
• The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
• The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1.
• The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1.
• Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.
• Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase
• Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae
• Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.